Lymphadenitis in Dogs and Cats

Swollen Lymph Nodes

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Updated on September 26, 2024
SUMMARY OF CONTENT
The term lymphadenopathy refers to enlarged lymph nodes. Lymph nodes can be enlarged for many reasons including infection and cancer. Lymphadenitis is the term used to describe a non-cancerous condition of the lymph nodes which are enlarged due to infection or inflammation.
SEVERITY:
Severity is moderate to severe

  • Diagnosis Icon
    Requires a diagnosis by a veterinarian
  • Time to Cure
    Resolves within weeks after treatment in some cases
  • Treatment Icon
    Treatable by a veterinarian and by the pet parent
  • Prevention Icon
    There is no known prevention
  • Spread Icon
    Some infectious causes of lymphadenitis may be transmissible to other animals or humans but most are not.
  • Lab Icon
    Diagnosis requires physical exam, fine needle aspirate and cytology of lymph nodes, lymph node biopsy, and often blood testing

VERY COMMON IN
Pets of any breed, age or gender can develop lymphadenitis.

Symptoms & Signs

Enlargement of one or more lymph nodes is the most common sign of lymphadenitis. Pet parents may notice a bump on their pet when they are petting them. It may be possible to see the enlarged lymph node under the fur. Enlarged lymph nodes can be found most often under the jaw, in front of the shoulder blade, behind the armpit, in the groin and behind the knee. If the lymphadenitis is due to infection, the pet may have a fever or act lethargic or not want to eat. Other symptoms may be displayed depending on the area involved. Enlarged lymph nodes under the jaw or throat may cause drooling, excessive swallowing, decreased appetite or a cough. Infections often travel toward the heart, so if an infection occurs in a foot, the lymph nodes further up the leg can be enlarged due to the infection fighting cells being stimulated. Infections and inflammation can be very painful, so limping or licking at affected areas may occur. Swollen lymph nodes are painful and muscle movement increases discomfort, so the pet may not be as active as usual. Seek veterinary care ASAP when you detect a new lump or your pet is painful, lethargic, or does not want to eat.

Diagnosis

Your veterinarian will begin with a physical examination of your pet. He or she will palpate the different locations where lymph nodes are found and check for enlargement. If an enlarged lymph node is found, your veterinarian needs to determine whether this enlargement is due to lymphadenitis, which is not cancerous, or to a cancer such as lymphoma. They will perform a fine needle aspirate of the lymph node with a tiny needle and obtain a cell sample for cytology, which is. evaluating the cell sample with special stains under a microscope. This helps differentiate lymph node enlargement from infection (lymphadenitis), from sterile inflammation, and from enlargement due to cancer such as lymphoma. If the cytology is not diagnostic or if there is concern for cancer, a biopsy may be needed. During a biopsy, a section of the lymph node is taken under heavy sedation or anesthesia and is submitted to a laboratory for histopathology . Your veterinarian may also recommend running blood tests to check for signs of infection.

Causation

There are many lymph nodes in the body. Lymph nodes are a type of gland and play a key role in the immune system. The function of a lymph node is to filter the blood and lymph and present foreign material such as bacteria, fungi or viruses to the infection fighting cells located in the lymph node. These cells then become activated and multiply as well as start releasing inflammatory enzymes and antibodies, causing the lymph node to become enlarged. This is called lymphadenitis.. The lymph nodes that drain an affected area become enlarged. For instance, if a pet has an infection in the gums, the submandibular lymph nodes (located under the jaw) will be enlarged as the blood and lymph from that area drain into these glands. . Sometimes lymphadenitis occurs due to an overreaction of the immune system, especially in dogs, and immunosuppressive therapy such as steroids are needed. 

Treatments

icon AT-HOME CARE
Administer medications as prescribed by your veterinarian.
icon SUPPORTIVE CARE
Depending on the cause, your pet may need IV fluid therapy, IV medications, and sometimes pain medication or compresses.
icon MEDICATIONS
Treatment for lymphadenitis is targeted at the cause for the inflammation. Antibiotics are used to treat bacterial infections; antifungal medications are used to treat fungal infections. Some viral infections can be treated with antiviral medications, others can only be treated with supportive care. Sterile lymphadenitis (no infectious cause present) usually is treated with anti-inflammatory steroids.
icon SPECIALISTS
A general practice veterinarian can diagnose and manage most cases of lymphadenitis. Some cases may be referred to a specialist in veterinary internal medicine.

Cost Of Treatment

The cost of treating lymphadenitis is generally under $1000. This may include exam, diagnostics and treatment(s).

Recovery

Lymphadenitis secondary to an infection or inflammation usually improves or resolves within days after starting appropriate medical treatments.

Monitoring

Follow-up depends on the cause of the infection or inflammation and your pet’s progress, but may involve additional examinations or laboratory testing..

Prevention

There is no known prevention for lymphadenitis; however, keeping your pet’s vaccines up to date and limiting contact with other animals may reduce the chance of developing some infections that cause lymphadenitis.

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Disclaimer

The information contained on this page is for educational purposes only. This medication should only be given under the advice of a veterinarian who has examined your pet under the laws applicable to your state of residence.