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Cetirizine in Veterinary Medicine - Facts and Information

Cetirizine

Updated on September 10, 2024

Cetirizine is an antihistamine medication most commonly used as an adjunctive treatment for itching associated with allergies. It is often used extra-label in veterinary medicine.

Cetirizine

Summary

Used For:

Itching associated with allergies, allergic reactions, blocking histamine release in mast cell tumor

Brands:

Zyrtec®, Piriteze®

Species:

Cats, Dogs, Horses

Drug type:

Antihistamine

Prescription required:

No

Pregnancy and lactation:

Likely safe for pregnant or lactating animals, but consult a veterinarian before use

Side effects:

Vomiting, hypersalivation (drooling), drowsiness
 

General description

Cetirizine is a second generation antihistamine medication that blocks the release of histamine, which is a substance that causes inflammation, skin redness, and swelling, often leading to itching. For this reason, cetirizine is typically used as an adjunctive treatment in the management of itching associated with allergies, allergic reactions, and blocking histamine release due to mast cell tumors. It is often used extra-label in veterinary medicine.

Uses

Itching associated with allergies, allergic reactions, and blocking histamine release in mast cell tumors

How it works

Cetirizine works by blocking H1 (histamine) receptors and decreasing the histamine release from basophils (a type of white blood cell) in some species.

Dosage

Dogs: 0.5-1 milligrams per kilogram of body weight by mouth once daily Cats: 5 milligrams per cat by mouth once daily Horses: 0.2-0.4 milligrams per kilogram of body weight by mouth every 12-24 hours

Forms

Cetirizine HCl coated and chewable tablets for oral use are available in 5 milligram & 10 milligram sizes. Cetirizine HCl liquid suspension for oral use is available in a 1 milligram per milliliter concentration.

Storage information & handling

Keep in the original package or a childproof container at room temperature, out of the reach of pets and children.

What results can I expect?

Improvement in itching associated with allergies, resolution of allergic reaction, and management of histamine release from mast cell tumor.

Missed Dosage

If a dose is missed, give the dose as soon as possible. If it is almost time for the next dose, skip the missed dose and give the next dose at the regularly scheduled time. Do not give two doses at once.

Overdose / acute toxicity

If an overdose is known or suspected, seek veterinary attention immediately. Signs of an overdose may include hyperactivity, vomiting, lethargy, panting, pupil dilation, and an increased heart rate.

Side effects

*Vomiting *Hypersalivation (drooling) *Drowsiness at higher doses

Contraindications

*Use with caution in patients with liver or kidney dysfunction *Use with caution in patients with previous sensitivity

Drug interactions

Medications that depress the central nervous system may interact with cetirizine. Discuss all medications and supplements with your veterinarian before administering any new medication.

Precaution

Due to limited experience in veterinary medicine, caution should be exercised with use in patients with existing liver or kidney disease, and reduced dosages are recommended.

Sources

Plumb’s Veterinary Drug Handbook

Related Questions

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My dog I heated uses tampon is it an emergency

Unfortunately I'm having a little trouble understand your question as I'm not sure what you mean by "My dog I heated uses tampons..." I'm wondering if Bella ate a tampon or if you wanted to use one on her while she is in heat. I will answer both to be safe. If she ate a tampon, then yes this is a medical emergency and she has to see a vet now. Tampons can easily cause obstructions in the GI tract, especially since they are absorbent and can get large in the stomach from liquid in there. if Bella ate a tampon, you need to take her into a vet immediately to get it removed. If she is on heat, no you cannot use a tampon to control her bleeding. It's not safe to use at all, and are not meant for dogs. You can put a diaper on her to catch any bloody discharge. There are dog specific diapers online and at pets stores, or you can use one made of a human child. Just cut a hole in it for her tail. Hopefully this answers your question. If it doesn't, I'm sorry and ask you post again in the forum for free to it can get answered!

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I'm glad to see that Pippin has been neutered because this eliminates that possibility of hormone-fueled behavioral changes and aggression. Behavioral changes in cats can occur at any point in time, and could be related to anxiety or stressful situations (even rearranging furniture or introducing new people to the home can be stressful to cats). Without a lot more information and observing Pippin's behaviors, I can't precisely tell you why these changes are occurring. It may be best to consult a veterinary behaviorist in your home so that they can observe everything firsthand. You can also try using calming pheromone collars or diffusers (Feliway is one example), and discussing the use of anxiety medication with Pippin's vet. I hope that all goes well!

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Disclaimer

The information contained on this page is for educational purposes only. This medication should only be given under the advice of a veterinarian who has examined your pet under the laws applicable to your state of residence.