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Cyproheptadine in Veterinary Medicine - Facts and Information

Cyproheptadine

Updated on September 10, 2024

Serotonin antagonist antihistamine used as an appetite stimulant in cats.

Cyproheptadine

Summary

Used For: Cyproheptadine is most commonly used as an appetite stimulant in cats.

Brands: Periactin, Ciplactin, Cyheptine, Periactinol

Species: Dogs, cats

Drug type: Antihistamine

Prescription required: Yes

Pregnancy and lactation: Safety in pregnant or lactating animals has not been established.

Side effects: Sedation, ataxia, dry mucous membranes, agitation

General description

Cyproheptadine is an antihistamine used as an appetite stimulant in cats. It has also been used as an antipruritic/antihistamine in dogs and cats for allergies and asthma, although the efficacy in uncertain. It may also be useful as adjunctive treatment in dogs or cats in the treatment of dysphoria associated with serotonin syndrome. [Buy Cyproheptadine now on Petco.](https://www.petco.com/shop/en/petcostore/brand/cyproheptadine) A prescription from your veterinarian may be needed to purchase.

Uses

Most commonly used as an appetite stimulant in cats. May also be used for allergies, asthma, and in the treatment of dysphoria associated with serotonin syndrome.

How it works

As an antihistamine, cyproheptadine counteracts histamine, which is a chemical released to cause inflammation and itchiness as part of an allergic reaction. In addition to its antihistamine effects, cyproheptadine also works as a serotonin antagonist. Serotonin is a neurotransmitter in the brain and when it is suppressed it causes an increase in appetite.

Dosage

**Dogs**: 1.1 milligrams per kilogram of body weight by mouth every 4 to 6 hours for serotonin syndrome, 0.3 – 2 milligrams per kilogram of body weight by mouth every 12 hours as an antihistamine **Cats**: 1 – 2 milligrams per cat by mouth every 12 – 24 hours as an appetite stimulant, 2 milligrams per cat by mouth every 12 hours as an antihistamine, 2 – 4 milligrams per cat by mouth every 4 – 6 hours for serotonin syndrome.

Forms

Cyproheptadine Oral Tablets 4 milligram tablets. Cyproheptadine HCl Oral Syrup: 2 milligrams per 5 milliliters

Storage information & handling

Tablets and Oral solution: stored at room temperature protected from moisture and light.

What results can I expect?

Increased appetite, decreased dysphoria, or resolution of clinical signs associated with allergies or asthma depending on why the medications were prescribed.

Missed Dosage

Give the dose as soon as possible. If it is almost time for the next dose, skip the missed dose, and continue with the regular schedule. Never give two doses at once.

Overdose / acute toxicity

Overdose can cause significant CNS depression and should be treated with gut emptying protocols and supportive therapy.

Side effects

May include: * Sedation/drowsiness * Ataxia * Agitation * Dry mouth * Vomiting * Diarrhea/Constipation * Urine retention * Tachycardia * Behavioral changes

Contraindications

Avoid use or use with caution in pets with: * Known hypersensitivity * Liver disease * Prostatic hypertrophy * Bladder neck obstruction * Epilepsy * Glaucoma * Hyperthyroidism * Gastrointestinal obstruction * Cardiac disease

Drug interactions

Consult your veterinarian before using cyproheptadine with any other medications, even vitamins and supplements. The following drugs may interact with cyproheptadine: * CNS depressant medications * Mirtazapine * Sertraline * Fluoxetine * Paroxetine * Clomipramine * Amitriptyline * Tramadol

Precaution

Use with caution in working animals since sedation may interfere with job performance. Not recommended for use in cats with hepatic lipidosis.

Sources

Plumb’s Veterinary Drug Handbook

VIN Veterinary Drug Handbook

Manufacturer information: Merck & Co., Inc. (Periactin)

Related Questions

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Disclaimer

The information contained on this page is for educational purposes only. This medication should only be given under the advice of a veterinarian who has examined your pet under the laws applicable to your state of residence.