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Lisinopril in Veterinary Medicine - Facts and Information

Lisinopril

Updated on September 10, 2024

Lisinopril is used to dilate blood vessels, aiding in the treatment of both heart failure and hypertension (high blood pressure).

Lisinopril

Summary

Used For: heart failure, hypertension (high blood pressure)

Brands: Zestril®, Prinivil®, Qbrelis®

Species: Dogs and cats

Drug type: Cardiac

Prescription required: Yes

Pregnancy and lactation: Not recommended for use in pregnancy. Use with caution in lactating animals

Side effects: Gastrointestinal upset (including anorexia, vomiting, and diarrhea), weakness, hypotension

General description

Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor that works to dilate blood vessels. This action is beneficial in the treatment of both heart failure and hypertension (high blood pressure) in dogs and cats. Lisinopril use in veterinary medicine is considered extra-label.

Uses

heart failure, hypertension (high blood pressure)

How it works

Angiotensin-converting enzyme (ACE) inhibitor that prevents the formation of substances responsible for constricting the blood vessels.

Dosage

Dogs: 0.5 milligrams per kilogram of body weight given by mouth every 12-24 hours. Cats: 0.25-0.5 milligrams per kilogram of body weight given by mouth once daily.

Forms

Lisinopril oral tablets available in 2.5 milligram, 5 milligram, 10 milligram, 20 milligram, 30 milligram, and 40 milligram sizes.

Storage information & handling

Lisinopril should be stored in a childproof container at room temperature in a safe location out of the reach of children and animals.

What results can I expect?

Improvement in blood pressure and clinical signs associated with heart failure.

Missed Dosage

It is best to give the medication as directed without skipping doses. If you miss a dose, skip the one you missed and go back to the normal schedule. Do not give two doses at the same time.

Overdose / acute toxicity

Overdoses may cause lethargy, increased heart rate, vomiting, and hypotension (low blood pressure). Seek veterinary care immediately if you think your pet has had an overdose.

Side effects

*Vomiting *Diarrhea *Anorexia *Cough *Weakness *Hypotension (low blood pressure) *Kidney dysfunction *Low potassium

Contraindications

*Previous sensitivity to ACE inhibitors *Use with caution in patients with renal insufficiency *Use with extreme caution in patients with low sodium and existing red or white blood cell abnormalities *Monitor closely with severe congestive heart failure

Drug interactions

Insulin and oral antidiabetic medication, diuretics (furosemide, spironolactone, hydrochlorothiazide), lithium, other medication to lower blood pressure, non-steroidal anti-inflammatory drugs (NSAIDs), and potassium supplements may all interact with lisinopril. Discuss all medications and possible interactions with your pet’s veterinarian.

Precaution

Avoid use in patients with previous sensitivities to ACE inhibitors. Use with caution in animals with kidney disease, low sodium, or blood cell changes. Avoid use in pregnant animals and use caution in lactating animals.

Sources

Plumb’s Veterinary Drug Handbook

Related Questions

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Disclaimer

The information contained on this page is for educational purposes only. This medication should only be given under the advice of a veterinarian who has examined your pet under the laws applicable to your state of residence.