Mirtazepine is an antidepressant medication most often used in human medicine. In veterinary medicine, it is primarily used in dogs and cats to increase appetite and improve signs of nausea associated with a variety of health conditions, including kidney disease.
Appetite stimulant, anti-nausea medication. Used extra-label in veterinary medicine
Mirtazapine causes increases in serum norepinephrine and blocks serotonin receptors, which may account for appetite stimulation and anti-nausea properties.
Store in a childproof container at room temperature, out of the reach of pets and children.
If a dose is missed, give the missed dose as soon as possible. If it is almost time for the next dose, skip the missed dose and give the next dose at the regularly scheduled time. Do not give two doses at once.
If an overdose is known or suspected, seek veterinary attention immediately. Signs of an overdose can include tremors, vocalization, agitation, panting, lethargy, vomiting, increased heart rate, and ataxia (abnormal, wobbly gait).
Clonidine, cyproheptadine, diazepam (and other benzodiazepines), linezolid, tramadol, amitraz, selegiline, and fluvoxamine can all interact with mirtazepine. Always discuss any medication or supplements with your veterinarian due to potential drug interactions.
Use with caution in patients with pre-existing heart disease or blood pressure changes, as well as changes in red or white blood cells, or platelets. Use with caution in pregnant or lactating animals.
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