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My senior dog started being restless and crying at night after giving her mirtazapine. I originally got it for her appetite, but it was also for mood elevation. I kept giving it to her after I saw that she kept crying at night, but now I’m scared she’s got serotonin syndrome. The dose is 7.5 twice a week, I’ve only done two doses this week. Today was the second one. If it is serotonin syndrome, will it go away on its own?

My senior dog started being restless and crying at night after giving her mirtazapine. I originally got it for her appetite, but it was also for mood elevation. I kept giving it to her after I saw that she kept crying at night, but now I’m scared she’s got serotonin syndrome. The dose is 7.5 twice a week, I’ve only done two doses this week. Today was the second one. If it is serotonin syndrome, will it go away on its own?

Updated On June 21st, 2020

Pet's info: Dog | Maltipoo | Female | spayed | 17 years and 8 months old | 11 lbs

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Answered By Jenna Beyer, DVM, MBA, cVMA

Veterinarian, Certified Veterinary Acupuncturist

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I don't think this is serotonin syndrome. That dose is well within the safe range for Brandy. It may be anxiety, pain, related to another medical issue, or even cognitive dysfunction syndrome in dogs. I would recommend discussing this new issue with Brandy's vet. They may have some more insight on what could be the cause based on her medical history and recent physical exam. It may also be that the mirtazapine is not a good match with any other medications she is on. You could try a different appetite stimulant, called Entyce, which is specifically labeled for dogs.

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