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Tylosin in Veterinary Medicine-Facts and Information

Tylosin

Updated on September 10, 2024

Antibiotic commonly used to treat chronic diarrhea in dogs and cats.

Tylosin

Summary

Used For: Chronic diarrhea, respiratory infections, skin infections

Brands: Tylan

Species:

Dogs cats, rabbits, ferret, avian species, reptiles and other pocket pet or livestock species

Other names: Tylosin hydrochloride, tylosin tartrate

Drug type: Antibiotic

Prescription required: Yes

Pregnancy and lactation: Use with caution in pregnant or lactating animals.

Side effects:

Rare, occasionally decreased or absent appetite and diarrhea if injected, pain and/or inflammation at the injection site may occur. 

General description

Tylosin is an antibiotic used to treat many different health concerns such as chronic diarrhea, certain respiratory and skin infections and occasionally inflimmation in several species. Buy [Tylosin](https://www.petco.com/shop/en/petcostore/product/tylan-oral-granules) now on Petco. A prescription from your veterinarian is required for purchase.

Uses

Chronic diarrhea, *Clostridium perfringens* diarrhea, inflammatory bowel disease, colitis, respiratory tract infections, some skin infections.

How it works

Tylosin kills bacteria by inhibiting the production of proteins.

Dosage

*Information provided below outlines what a typical dose might look like. Always consult your veterinarian on the appropriate dose for your specific animal when using any vitamin, supplement, off-label or prescription products. Some vets may prescribe outside of these ranges based on specific needs of the patient. **Dogs**: 10-40 milligrams per kilogram by mouth every 8-12 hours. **Cats**: 10-40 milligrams per kilogram by mouth every 8-12 hours. The medication dosages listed represent the variation in dosing for all underlying medical conditions. Medications should only be administered to pets under the direct guidance of a veterinarian.

Forms

Tylosin is available as an implant, medicated feed premix and solution for the use in large animals. Tylosin is also available as an oral medication, implant,injection, or medicated feed premix and solution for the use in large animals. 1000 milligrams per gram tylosin soluble granules, 1000 milligrams per gram tylosin soluble powder. Tylosin may also be an active ingredient included in implants.

Storage information & handling

Tylosin should be stored at room temperature in an airtight container. See label for injectable or implant formulations. 

What results can I expect?

Assuming that the infection being treated is susceptible to tylosin, resolution of the infection should occur during the treatment period. For the treatment of chronic diarrhea, most animals will show improvement while being treated with tylosin.

Missed Dosage

If a dose is missed, give it as soon as you remember or if the next dose time is coming up soon, skip the missed dose and continue with the next dosage at the scheduled time.

Overdose / acute toxicity

Tylosin is relatively safe and overdoses are generally well tolerated. Vomiting and diarrhea may occur. Contact your veterinarian or the Pet Poison Hotline if your pet is experiencing abnormal health concerns. 

Side effects

Tylosin is generally well tolerated and side effects are rare. Occasionally, decreased or absent appetite and diarrhea may be seen.

Contraindications

*Do not use in animals with a known hypersensitivity to tylosin.

Drug interactions

Drug interactions are not well established with Tylosin. If your pet is on digoxin for heart failure Tylosin may increase the level of digoxin in your pet's blood levels and should only be used with caution and the support of your veterinarian. Use Tylosin with products listed below with caution and only with the advice of your veterinarian as there may be contraindications similar to erythromycin: **antifungals **cisapride **chloramphenicol **clindamycin **diltiazem **omeprazole **sucralfate **certain chemotherapy agents **cyclosporine **midazolam **alprazolam **Theophylline

Precaution

Prolonged or repeated use of antibiotics may cause the development of resistant bacteria.

Sources

*Plumb’s Veterinary Drug Handbook*

Related Questions

Hi! My cat was recently diagnosed with diabetes. He’s taking insulin and taking antibiotics for a Uti. It’s been 4 weeks and he wobles when he’s walking. He can’t jump up on the bed like he used to.He’s blood sugar is 250 it’s better than it used to. I don’t understand why he’s so wobbly.

Cats can develop what's called diabetic neuropathy, where their hindlegs become progressively weak. The best thing to do is try to get his diabetes under control as quickly as possible. Here is a link describing the conditon: http://www.diabeticcatcare.com/DCCCOK/Neuropathy.htm

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Is there a reason you want to stop the prednisone? I would recommend not stopping it and if you feel it is better to stop the prednisone then I would recommend weaning off of the prednisone. I would discuss how to wean the prednisone with your veterinarian. Thank you for using Boop by Petco.

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My dog vomited a pinkish colour. Does this look like blood vomit? She doesn’t have diarrhoea or anything else. Yesterday i fed her plain chicken with rice.

That is very red vomit, however, this color could be linked to a number of things including blood in the vomit, inflammation of the GI tract, having chewed on a toy this color, eaten a food item this color, or gotten into a plant or other item this color. If the vomiting continues, worsens, or other symptoms appear such as a painful or bloated abdomen, diarrhea or blood in the stool, or severe distress, I would schedule a veterinary appointment right away to rule out more severe issues. In the meantime I would continue the bland diet for 24 hours, and monitor for any additional vomiting or illness symptoms.

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In severe outbreaks, 2 weeks between different drugs is ok. You will also need to use a household flea treatment in order to break the cycle, only 5% of the flea population are adults and actually present on pets, tge remaining 95% are eggs/large and will continue to hatch, develop and reinvest your pets. All in contact animals should be treated together and also given a tapeworm treatment because tapeworms are also transmitted by fleas

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My 8yo Golden had a falsepregnancy w milk. Cabergoline has resolved it now. I hear conflicting opinions about spaying. She has never mated. Some say not spaying would cause pseudopregnancy recurrence+dangerous conditions like Mammary T. But UCDavis studies say spaying increases other aggressive cancer risks among GoldenRs. Also, vet thinks that her anemia that keeps coming back after prednisolone trtmnts *might* be due to Ovary cysts, suggests spaying. What's the right approach for her health?

Thank you for contacting Boop by Petco with your question about Lav. I've heard many owners quote the UC Davis study, and there are a number of things wrong with the study. Check out this article on it: https://humanepro.org/magazine/articles/deconstructing-spayneuter-debate Not spaying her can cause a pseudopregnancy reoccurrence, but it doesn't increase her risk of mammary tumors. That's already going to be 25% because she's had more than two heats. Keep in mind, 50% of mammary tumors in dogs are malignant. She is eight years old, so she is already at a higher risk of developing cancer simply because she is an older dog. She is also at risk of a pyometra, which is an infection of the uterus that is fatal without treatment. The treatment for a pyometra is spaying the dog, which is an emergency during a pyometra and can cost many thousands of dollars. In all honesty, it's best to spay her. It will keep her from developing a pyometra as well as a pseudopregnancy, and it will keep her from getting pregnant if she accidentally mates. Dogs over the age of six should never have puppies. In my opinion, it's best for her to health to get spayed asap. I hope this helps!

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My cat was prescribed antibiotics for diarrhea and today was his second day of taking them. He’s required to take 0.5 mL of the antibiotic and another one after 12 hours (twice a day). Today, he lost his appetite (only ate a few treats) and threw up clear liquid twice and clear yellow liquid 3 times. He is also lethargic.

Hello, thank you for using Boop by Petco. I'm sorry to hear that Leo is having this problem. Many antibiotics cause gastrointestinal issues in cats so you will need to call your vet and let them know what is going on. Most likely they will have you stop one or both of the antibiotics and prescribe something different. I would also suggest that you put him on a pre/probiotic while he is taking antibiotics and then continue for at least one week after the antibiotics have been stopped. Hope this helps. Best wishes.

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Disclaimer

The information contained on this page is for educational purposes only. This medication should only be given under the advice of a veterinarian who has examined your pet under the laws applicable to your state of residence.