Amikacin is an injectable aminoglycoside antibacterial used to treat aerobic gram-negative bacterial infections not responsive to more commonly used antibiotics. It is typically used in veterinary medicine to treat serious respiratory, urogenital, skin, and soft tissue infections.
Bacterial infections including urinary tract infections, respiratory tract infections, skin infections, soft tissue infections, and uterine infections.
Amikacin is a bactericidal antibiotic that stops bacterial growth by inhibiting protein synthesis in susceptible bacteria.
Store at room temperature.
Give the dose as soon as possible. If it is almost time for the next dose, skip the missed dose, and continue with the regular schedule. Never give two doses at once.
Early signs of toxicity include loss of balance and vomiting. May see symptoms of kidney disease including increase or decrease in drinking, lack of appetite, vomiting, depression, coma, and death.
Amikacin should be used cautiously with other drugs that may cause hearing loss, vestibular disease, or kidney disease. These include: * Amphotericin B * Other aminoglycosides * Acyclovir * Bacitracin * Cephalosporins * Cisplatin * Diuretics * Methoxyflurane * Polymyxin B * Vancomycin General anesthesia and neuromuscular blocking agents may also interact with amikacin.
Young and old pets are at increased risk of side effects. Cats are very sensitive to the vestibular effects of aminoglycosides. Do not use in animals who require their hearing to perform their work due to the risk of permanent hearing loss or vestibular impairment. A culture and sensitivity test should be performed to verify the need for amikacin due to the seriousness of potential side effects.
Baseline bloodwork and urinalysis (to specifically identify casts) should be obtained prior to using this medication and should be repeated during treatment to monitor kidney function.
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