Phenylbutazone

Updated on September 10, 2024

Phenylbutazone is a non-steroidal anti-inflammatory drug used to treat conditions that create inflammation in domestic species. Due to the availability of safer and more effective options, this medication is rarely used in dogs, cats, and other small animals.

Phenylbutazone

Summary

Used For: Inflammation, osteoarthritis, soft tissue injury

Brands: Butazolidin, Phenylbute

Species:

Horses, cattle, pigs, rarely used in dogs, cats and other small animals

Other names: Bute

Drug type: Anti-Inflammatory

Prescription required: Yes

Pregnancy and lactation:

Safety for use in pregnant and lactating animals has not been established.

Side effects: GI upset, jaundice, weakness, rapid breathing or seizures

General description

Phenylbutazone is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation of soft tissues, muscles and bones. Newer, safer medications are available for dogs; however, phenylbutazone may be recommend by a veterinarian in select cases. The manufacturer recommends monitoring for anemia, low platelet and white blood cell counts, and liver and kidney damage.

Uses

Inflammation, pain, osteoarthritis, soft tissue injury, other inflammatory conditions.

How it works

Phenylbutazone disrupts the production of inflammatory prostaglandins in the body.

Dosage

**Dogs**: 14.7 milligrams per kilogram of body weight given orally every 8hours initially then titrate down to lowest effective dose.

Forms

100, 200, 400 milligram tablets and 1 gram tablets are available; 200 milligram/milliliter injectable solution.

Storage information & handling

Tablets: keep dry and away from sunlight. Injectable solution must be kept refrigerated.

What results can I expect?

Phenylbutazone begins working to decrease pain and inflammation within 1-3 hours after the first dose.

Missed Dosage

If a dose is missed, continue the next dose at the scheduled time.

Overdose / acute toxicity

Overdose can cause severe gastrointestinal upset, seizures, and kidney or liver failure.

Side effects

May include: * Diarrhea * Vomiting * Blood in the stool * Seizures * Jaundice * Weakness * Rapid breathing

Contraindications

Do not use in patients with: * Liver disease * A history of seizures * Sensitive gastrointestinal systems * Kidney disease

Drug interactions

Phenylbutazone should not be used in combination with any other medication that is a steroid or a non-steroidal anti-inflammatory drug (NSAID).

Precaution

This medication is no longer considered safe for small animals. Many other options are now available. Use in horses is still common and well-tolerated by this species.

Sources

*Saunders Handbook of Veterinary Drugs*
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Disclaimer

The information contained on this page is for educational purposes only. This medication should only be given under the advice of a veterinarian who has examined your pet under the laws applicable to your state of residence.