Updated On February 15th, 2016
Pet's info:
Answered By Destini R. Holloway, DVM 87
Veterinarian
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You can breed a sister and brother but is is not recommended because this is considered in-breeding and poses the risk of selecting for certain genes that can lead to increased chance of a lot of disease processes and abnormalities.
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Other Answers
Answered By Bette Isacoff
Dog Trainer
Even though they are from different litters, they still have the same sire and dam. Therefore, they are too closely related to be bred to each other.
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Answered By Andrea M. Brodie, DVM
Veterinarian
In the interest of genetic diversity it is not recommended. Brother X Sister is called "inbreeding". Inbreeding is used to enhance positive traits as the chance of these traits being manifested in offspring is heightened. Unfortunately, unwanted traits also manifest much easier, so inbreeding is reserved for only the most educated breeders. So while it is possible, I do not recommend inbreeding.
60Pet Parents found this answer helpful